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Kenneth P. Kaufman

Kenneth P. Kaufman

BSChE 1981 began his professional career at Dow Corning in 1981 as a process design engineer. His...
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Established in 1933, the Wayne State University College of Engineering has a long history of improving quality of life through education, innovation and entrepreneurship.

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Graduate Resumes for Industry Webinar
October 7 2015 at 12:00 PM
Online Programs
WSU graduate students & Postdocs will review the steps in creating a resume that highlights projects, research activity and education for a job in industry.
Lipids@Wayne with Gabor Tigyi MD PhD
October 7 2015 at 5:00 PM
Biological Sciences
Lipids@Wayne and the Office of the Vice President of Research are pleased to announce the next Lipids@Wayne seminar on Wednesday, October 7, 2015 at 5:00 pm in 1167 Biological Science Building.  The seminar is free and open to the public.  Refreshments will be served. Speaker: Gabor Tigyi, MD PhD; VanVleet Endowed Professor and Chair, Department of Physiology, University of Tennessee Health Science Center Memphis Title: Curing Radiation Injury Using Rationally-Designed Analogues of Lysophospholipids Abstract: Pharmacological mitigation of injuries caused by high-dose ionizing radiation is an unsolved medical problem. A specific nonlipid agonists of the type 2 GPCR for lysophosphatidic acid (LPA2) 2-[4-(1,3-Dioxo-1H,3H-benzoisoquinolin -2-yl)butylsulfamoyl]benzoic acid (DBIBB) when administered with a postirradiation delay up to 72 hours reduced mortality of C57BL/6 mice but not in LPA2 KO mice. DBIBB mitigated the gastrointestinal radiation syndrome (Fig.1), increased intestinal crypt survival and enterocyte proliferation, and reduced apoptosis. DBIBB enhanced DNA repair by augmenting the resolution of H2AX foci, increased clonogenic survival of irradiated IEC-6 cells, attenuated the radiation-induced death of human CD34+ hematopoietic progenitors and enhanced the survival of the granulocyte/macrophage lineage. DBIBB also increased the survival of mice suffering of the hematopoietic acute radiation syndrome after total body irradiation. DBIBB represents the first drug candidate capable of mitigating acute radiation syndrome caused by high-dose g-radiation to the hematopoietic and gastrointestinal system. We have also characterized the effects of radiation injury on the expression and function of the autotaxin (ATX)-LPA2 GPCR axis. In IEC-6 crypt cells and jejunum enteroids quantitative RT-PCR showed a time- and dose-dependent upregulation of lpa2 in response to g-irradiation that was abolished by mutation of the NF-kB site in the lpa2 promoter or by inhibition of ATM/ATR kinases with CGK-733, suggesting that lpa2 is a DNA damage response gene upregulated by ATM via NF-kB. The resolution kinetics of the DNA damage marker γ-H2AX in LPA-treated IEC-6 cells exposed to γ-irradiation was accelerated compared to vehicle, whereas pharmacological inhibition of LPA2 delayed the resolution of γ-H2AX. In LPA2-reconstituted MEF cells lacking LPA1&3 the levels of γ-H2AX decreased rapidly, whereas in Vector MEF were high and remained sustained. Inhibition of ERK1&2 or PI3K/AKT signaling axis by pertussis toxin or the C311A/C314A/L351A mutation in the C-terminus of LPA2 abrogated the effect of LPA on DNA repair. LPA2 transcripts in Lin-Sca-1+c-Kit+ enriched for bone marrow stem cells were 27- and 5-fold higher than in common myeloid or lymphoid progenitors, respectively. Furthermore, after irradiation higher residual γ-H2AX levels were detected in the bone marrow or jejunum of irradiated LPA2-KO mice compared to WT mice. We found that g-irradiation increases plasma ATX activity and LPA level that is in part due to the previously established radiation-induced upregulation of TNFa. These findings identify ATX and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair.  
PAD Seminar – External Funding: Insights to Professional Foundations
October 8 2015 at 1:00 PM
5057 Woodward
The offices of the Vice President for Research, Provost, and Faculty Affairs (School of Medicine) are pleased to offer the Professional and Academic Development seminar series for WSU faculty, chairs & directors, postdoctoral trainees & graduate students, and administrators.  Seminars are free, but registration is required. For this seminar, External Funding:  Insights to Professional Foundations, we will place emphasis on finding funding prospects and managing relationships with foundations.  The seminar will take place Thursday, October 8th, 2015, from 1:00-2:30 p.m. at 5057 Woodward, 6th Floor, Conference Room A. Topics will include: Working with Foundation Relations Resources for Finding Funding Interacting with Foundations Leveraging Grant Funds And more! Speakers will be Heidi Coates, director for Foundation Relations, Julianne Bjarnesen, assistant director for Foundation Relations, and Julie Burtch, foundation relations officer   Hope to see you there!    
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