Howard Matthew
Education
Postdoctoral, Harvard Medical School & Massachusetts General Hospital, 1994.
Ph.D., Wayne State University, Chemical Engineering, 1992.
M.S., Wayne State University, Chemical Engineering, 1987.
B.S., University of the West Indies, Chemical Engineering, 1984.
Research Interests
- Tissue Engineering of Cardiovascular, Neural and Liver Systems
- Polymeric Biomaterials: Natural & Synthetic
- Stem Cells (Cord Blood & Mesenchymal) for Regenerative Medicine
- Cell-Material Interactions: Designing, Modeling, Measuring
Research Statement and Highlights:
Our research is focused on the application of biologically-active polysaccharide materials and adult stem cells to problems in tissue engineering and regenerative medicine. Materials of particular interest, include chitosan and the glycosaminoglycans (GAGs). We are currently examining their use as components of tissue scaffolds and bioactive surfaces in a number of tissue regeneration and tissue modeling projects.
Heart Valves & Large Blood Vessels for Pediatric Patients: In collaboration with the Children’s Hospital of Michigan, we are engineering transplantable heart valve tissue with the goal of reducing the number of surgies needed for replacement of defective heart valves and vessels in newborns. Modified chitosan is being used as the foundation for heart valve tissue scaffolds. The ultimate goal is to implant a living valve derived from the patient’s own tissue, that can grow and adapt as the child grows.
Expansion and Differentiation of Hematopoietic Stem Cells: Hematopoietic Stem Cells (HSCs) are needed for restoration of bone marrow function and various cancer therapies. In our laboratory, synergism between matrix factors and cytokines is being studied to manipulate the balance between stem cell and growth and differentiation. Results are incorporated into perfusion bioreactor systems for high yield expansion of either HSCs or therapeutically valuable blood cells.
Liver Regeneration via Hepatocyte Transplantation: There is a current need to expand the quantity of liver tissue available for transplantation. We are developing technology to allow transplantation of hepatocytes and to facilitate their assembly and growth into a functional organ. Tissue engineering of implantable liver systems is limited in part by the high metabolism of this tissue and slow blood vessel growth in vivo. We are using computational fluid dynamic (CFD) modeling to design scaffolds that provide supplemental oxygenation of the incorporated cells in the short term and enhanced angiogenesis in the long term.
Publications
- Uygun BE, Bou-Akl T, Albanna M, Matthew HW (Jun 2010) Membrane thickness is an important variable in membrane scaffolds: Influence of chitosan membrane structure on the behavior of cells., Acta biomaterialia, 6 (6), 2126-31
- Sosne G, Qiu P, Kurpakus-Wheater M, Matthew H (Apr 2010) Thymosin beta4 and corneal wound healing: visions of the future., Annals of the New York Academy of Sciences, 1194, 190-8
- Uygun BE, Stojsih SE, Matthew HW (Nov 2009) Effects of immobilized glycosaminoglycans on the proliferation and differentiation of mesenchymal stem cells., Tissue engineering. Part A, 15 (11), 3499-512
- Aggarwal D, Matthew HW (Jun 2009) Branched chitosans II: Effects of branching on degradation, protein adsorption and cell growth properties., Acta biomaterialia, 5 (5), 1575-81
- Yu H, VandeVord PJ, Mao L, Matthew HW, Wooley PH, Yang SY (Feb 2009) Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization., Biomaterials, 30 (4), 508-17
- Patel M, Vandevord PJ, Matthew HW, Desilva S, Wu B, Wooley PH (Dec 2008) Functional gait evaluation of collagen chitosan nerve guides for sciatic nerve repair., Tissue engineering. Part C, Methods, 14 (4), 365-70
- Patel M, VandeVord PJ, Matthew HW, De Silva S, Wu B, Wooley PH (Sep 2008) Collagen-chitosan nerve guides for peripheral nerve repair: a histomorphometric study., Journal of biomaterials applications, 23 (2), 101-21
- Patel M, VandeVord PJ, Matthew HW, De Silva S, Wu B, Wooley PH (Sep 2008) Collagen-chitosan nerve guides for peripheral nerve repair: a histomorphometric study., Journal of biomaterials applications, 23 (2), 101-21
- Yu H, Vandevord PJ, Gong W, Wu B, Song Z, Matthew HW, Wooley PH, Yang SY (Mar 2008) Promotion of osteogenesis in tissue-engineered bone by Pre-seeding endothelial progenitor cells-derived endothelial cells., Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Yu H, Matthew HW, Wooley PH, Yang SY (Mar 2008) Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites., Journal of biomedical materials research. Part B, Applied biomaterials
- Cho CH, Eliason JF, Matthew HW (Oct 2007) Application of porous glycosaminoglycan-based scaffolds for expansion of human cord blood stem cells in perfusion culture.
- Aggarwal D, Matthew HW (Jul 2007) Branched chitosans: effects of branching parameters on rheological and mechanical properties., Journal of biomedical materials research. Part A, 82 (1), 201-12
- Uygun K, Matthew HW, Huang Y (Jun 2007) Investigation of metabolic objectives in cultured hepatocytes., Biotechnology and bioengineering, 97 (3), 622-37
- Uygun K, Matthew HW, Huang Y (Jun 2007) Investigation of metabolic objectives in cultured hepatocytes., Biotechnology and bioengineering, 97 (3), 622-37
- Sullivan JP, Gordon JE, Bou-Akl T, Matthew HW, Palmer AF (2007) Enhanced oxygen delivery to primary hepatocytes within a hollow fiber bioreactor facilitated via hemoglobin-based oxygen carriers., Artificial cells, blood substitutes, and immobilization biotechnology, 35 (6), 585-606
- Patel M, Vandevord PJ, Matthew H, Wu B, DeSilva S, Wooley PH (Nov 2006) Video-gait analysis of functional recovery of nerve repaired with chitosan nerve guides., Tissue engineering, 12 (11), 3189-99
- Vlahos AL, Crawford RS, Matthew HT, Ledgerwood AM, Lucas CE (Sep 2005) Effect of albumin and Hespan on rodent hepatocyte function after hemorrhagic shock and sepsis., The Journal of trauma, 59 (3), 583-8
- Calonder, C, Matthew, HWT, Van Tassel, P (2005) Adsorbed layers of oriented fibronectin: A strategy to control cell-surface interactions, Journal of Biomedical Materials Research, Part A, 75 (2), 316-323
- Chaikof EL, Matthew H, Kohn J, Mikos AG, Prestwich GD, Yip CM, Biomaterials and scaffolds in reparative medicine, Annals of the New York Academy of Sciences, 961, 96-105, June 2002
- Chaikof E, Matthew H, Kohn J, Prestwich GD, Mikos A, Yip C, Bioscaffolds for tissue repair: breakout session summary, Annals of the New York Academy of Sciences, 961, 112-3, June 2002
- Prestwich GD, Matthew H, Hybrid, composite, and complex biomaterials, Annals of the New York Academy of Sciences, 961, 106-8, June 2002
- VandeVord PJ, Matthew HW, DeSilva SP, Mayton L, Wu B, Wooley PH, Evaluation of the biocompatibility of a chitosan scaffold in mice, Journal of Biomedical Materials Research, 59(3), 585-90, March 2002
- VandeVord PJ, Matthew HW, DeSilva SP, Mayton L, Wu B, Wooley PH (Mar 2002) Evaluation of the biocompatibility of a chitosan scaffold in mice., Journal of Biomedical Materials Research, 59 (3), 585-90
- Suh JK, Matthew HW, Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review, Biomaterials, 21(24), 2589-98, December 2000
- Chupa JM, Foster AM, Sumner SR, Madihally SV, Matthew HW, Vascular cell responses to polysaccharide materials: in vitro and in vivo evaluations, Biomaterials, 21(22), 2315-22, November 2000
- Vlahos AL, Matthew H, Yu P, Lucas CE, Ledgerwood AM, Effects of physiologic albumin and hespan levels on hepatocytes in vitro, Journal of Trauma, 48(6), 1075-80, June 2000
- Sechriest VF, Miao YJ, Niyibizi C, Westerhausen-Larson A, Matthew HW, Evans CH, Fu FH, Suh JK, GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis, Journal of Biomedical Materials Research, 49(4), 534-41, March 2000
- Madihally SV, Matthew HW, Porous chitosan scaffolds for tissue engineering., Biomaterials, 20(12), 1133-42, June 1999
- Madihally SV, Flake AW, Matthew HW, Maintenance of CD34 expression during proliferation of CD34 cord blood cells on glycosaminoglycan surfaces, Stem Cells, 17(5), 295-305, 1999
- Surapaneni S, Pryor T, Klein M D, Matthew H W, Rapid hepatocyte spheroid formation: optimization and long-term function in perfused microcapsules., Asaio Journal, 43(5), M848-53, September 1997
- Stefanovich P, Matthew HW, Toner M, Tompkins RG, Yarmush ML, Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphology, Journal of Surgical Research, 66(1), 57-63, November 1996
- Stefanovich P, Matthew HW, Toner M, Tompkins RG, Yarmush ML (Nov 1996) Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphology., The Journal of surgical research, 66 (1), 57-63
- Matthew HW, Sternberg J, Stefanovich P, Morgan JR, Toner M, Tompkins RG, Yarmush ML (Jul 1996) Effects of plasma exposure on cultured hepatocytes: Implications for bioartificial liver support., Biotechnology and bioengineering, 51 (1), 100-11
- Stefanovich, P, Matthew, H.W.T, Toner, M, Tompkins, R.G, Yarmush, M.L., Extracorporeal Plasma Perfusion of Cultured Hepatocytes: Effect of Intermittent Perfusion on Hepatocyte Function and Morphology, Journal of Surgical Research, 65, 1996
- Matthew, H.W.T, Stefanovich, P, Morgan, J.R, Toner, M, Tompkins, R.G, Yarmush, M.L., Effects of Plasma Exposure on Cultured Hepatocytes: Implications for Bioartificial Liver Support, Biotechnology and Bioengineering, 51, 100-111, 1996
- Rotem A, Matthew HW, Hsiao PH, Toner M, Tompkins RG, Yarmush ML (Apr 1995) The activity of cytochrome P450IA1 in stable cultured rat hepatocytes., Toxicology in vitro : an international journal published in association with BIBRA, 9 (2), 139-49
- Rotem, A, Matthew, H.W.T, Hsaio, P.H, Toner, M, Tompkins, R.G, Yarmush, M.L., The Activity of Cytochrome P-450 IA1 in Stable Cultured Rat Hepatocytes., Toxicology In Vitro, 9, 139-149, 1995
- Matthew H W, Basu S, Peterson W D, Salley S O, Klein M D, Performance of plasma-perfused, microencapsulated hepatocytes: prospects for extracorporeal liver support., Journal of Pediatric Surgery, 28(11), 1423-7; discussion 1, November 1993
- Matthew HW, Basu S, Peterson WD, Salley SO, Klein MD (Nov 1993) Performance of plasma-perfused, microencapsulated hepatocytes: prospects for extracorporeal liver support., Journal of pediatric surgery, 28 (11), 1423-7; discussion 1427-8
- Matthew H W, Salley S O, Peterson W D, Klein M D, Complex coacervate microcapsules for mammalian cell culture and artificial organ development., Biotechnology Progress, 9(5), 510-9, September 1993
- Matthew H W, Salley S O, Peterson W D Jr, Deshmukh D R, Mukhopadhyay A, Klein M D, Microencapsulated hepatocytes. Prospects for extracorporeal liver support., Asaio Transactions, 37(3), M328-30, July 1991
- Matthew HW, Salley SO, Peterson WD, Deshmukh DR, Mukhopadhyay A, Klein MD, Microencapsulated hepatocytes. Prospects for extracorporeal liver support., ASAIO transactions / American Society for Artificial Internal Organs, 37 (3), M328-30
- Matthew HW, Salley SO, Peterson WD, Klein MD, Complex coacervate microcapsules for mammalian cell culture and artificial organ development., Biotechnology progress, 9 (5), 510-9
Professional Affiliations
- American Chemical Society
- American Institute of Chemical Engineers
- Biomedical Engineering Society
- Society for Biomaterials
- Tissue Engineering & Regenerative Medicine International Society
Awards and Honors
- 1996-2000, CAREER Award, National Science Foundation, Wayne State University
- 1992-1994, John Burke, Postdoctorall Fellowship, National Institutes Health, Harvard University
Accomplishments
- January 23, 2012
Howard Matthew, was elected to the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE). AIMBE is the leading advocacy group for medical and biological engineering and is comprised of some of the most important leaders in science and engineering, the top 2 percent of medical and biological engineers.
In the News
- Howard Matthew was featured on mitechnews.com for being elected to the College of Fellows of the American Institute for Medical and Biomedical Engineering.
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