Chaoyang Chen

Chaoyang Chen

Associate Professor, Research, Department of Biomedical Engineering, Director of Robotic Rehabilitation Lab, Wayne State University. Research Scientist and Director for Research, Orthopaedic Surgery and Sports Medicine, Detroit Medical Center

Contact

Chaoyang Chen

Biography

Dr. Chen received MD degree in Fujian Medical University, China in 1987 and completed orthopaedic residency training and orthopedic graduate education (PhD) in Peking University Health Science Center, China in 1990. He practiced orthopaedic surgery in Fujian Medical University and conducted orthopedic biomechanical research from 1990 to1994. He was selected as an International Fellow by the International Society for the Study of Lumbar Spine (ISSLS) in 1994. He won a Postdoctoral Fellowship Award from Arthritis Foundation and completed postdoctoral training at the Bioengineering Center, Wayne State University in 1998.  His research interests include neurophysiology of orthopaedic pain,  orthopaedic biomechanics,  robotic rehabilitation engineering, sports medicine injury prevention and performance enhancement, computer vision and machine learning algorithms for medical image processing. His research expertise includes lower back pain, whiplash pain, nerve tissue (brain and peripheral nerve) injury tolerance; ultrasonic surgical cutting device safety evaluation; muscular electrical signal (EMG) and nerve signal  digital processing and pattern recognition;  EEG signal controlled robotic exoskeleton; EMG controlled upper arm robotic exoskeleton; nano graphene implantable electrodes for peripheral neural interface (PNI), vehicle human interface (VHI) for drowsy driving monitoring, driver comfort enhancement and muscle fatigue prevention. His research has won awards from prestigious orthopedic research society and car crash conferences with more than 80 articles published in journals.

Education

  • MD: Medicine, Fujian Medical University, Fujian, China, 1982- 1987
  • PhD: Orthopaedics/Biomechanics, Peking University Health Science Center , Beijing, China 1987-1990
  • Orthopaedic Surgery Residency: Deaprtment of Orthpaedic Surgery, People's Hospital, Beijing, China 1987-1990
  • Research Fellow: Biomechanics Lab, Department of Civil Engineering, Fuzhou University, Fujian, China 1992-1994  
  • Post doctor of Injury Biomechanics and Neurophysiology, Wayne State University, Detroit, Michigan, USA, 1994-1997

Courses Taught

BME 4010: Engineering Physiology Laboratory
Measurement and analysis of physiological signals on living systems, with focus on neural, cardiovascular, respiratory and muscular systems. Includes a student-designed experiment on a physiological system, data collection, digital signal processing, statistcial analysis. 

BME7670: Experimental Methods in Physiology

This course introduces basic principles and techniques for monitoring, signal processing, and reading electromyography (EMGs), electroencephalography (EEGs), electro-cardiology (ECGs), galvanic skin response and polygraph (electro-dermal activity, EDA) , human acceleration response, and neurophysiology. This course also introduces basic human machine interface and application of human electrophysiology signal processing in robot control. Artificial intelligent (AI) and statistics-based machine learning will also be introduced.


Study Abroad Program: Physilogical Signal Processing for Human Machine Interface
http://studyabroad.wayne.edu/program/program.php?id=64&section=overview

Research Interests

• Clinical Orthopaedics and Sports Medicine Research
• Artificial Intelligence (AI) in Sports Medicine Radiology and Image Processing
• Neuroscience and Robotics
• Laboratory Robotic Engineering and Clinical Rehabilitation
• Artificial Intelligence and Machine Learning in Athlete Training System
• Sports Medicine Injury Prevention and Performance Enhancement
• Orthopaedic Laboratory Biomechanics
• Human Vehicle Interaction
• Automotive Occupant Safety

 

 

Teaching Interests

 Experimental Methods in Physiology

Physiologic Signal Processing for Human Machine Interface

Engineering Physiology Laboratory

Research Projects

Mind Controlled Prosthetic Hand

https://youtu.be/7YOI0gNigpA

https://youtu.be/SX7GMH6O0-g

 

Biomedical Signal Processing and Control using Machine Learning AI techniques

EMG controlled upper arm robotic exoskeleton using AI and machine leaning algorithms.  

https://youtu.be/vhHnssZ2ztM

 

Muscular Electrical Singal (EMG) Controlled Prosthetic Hand (signal chaneel, less complex)(FFT processing STM32)

https://youtu.be/sdbejKvOBn4


 

Compuer Controlled Lower Limb Exoskeleton Ambulation System

https://youtu.be/LCKVPwU-YE0

https://youtu.be/uX-7FhosAs0

 

EMG controlled arm prosthesis

https://youtu.be/d0Aqag-SlBE

 


Trajectory Control mechanisms

https://youtu.be/aEr_9O6QQfA

Real-time Adaptive Control mechanisms

https://youtu.be/SEnIn8svfec

 

Brain Wave Controlled Toy Car

https://youtu.be/J7G2F3o3_mY

 

Miniature Robot and Kinect Control

1. Standing and Sitting    https://youtu.be/i8aAwdgyaSI

2. Walking                        https://youtu.be/RQFa-vNKMe8

 

Publications

Book Chapters

Chaoyang Chen. Low-Cost Development of High Quality Automotive Safety Products. In Li Li & Yu Dong, Detroit: Butt China Automotive Industry (Chinese Edition). Economic Science. Press:Beijing, China. ISBN978-7-5141-4628-8, 2014, page 130-135.

John M Cavanaugh, Chaoyang Chen, Srinivasu Kallakuri. Thoracolumbar Pain: Neural Machanisms and Biomechanics. In: Accidental Injury: Biomechanics and Prevention. Edited by Narayan Yoganandan, Alan M. Nahum, John W. Melvin, ISBN 978-4939-1731-0. DOI 10.1007/978-1-4939-1732-7 2015,  Springer:New York, Page 581-611. 

 

Professional Affiliations

  • Biomedical Engineering Society (2010-2015) 
  • Orthopaedic Research Society (1999 to present)
  • Society for Neuroscience (1998 to present)
  • Associate of NIH Directors, Council of Public Representatives (COPR), 2006-2008
  • Fujian Province Biomechanics Society (1992-1994)

 

Papers and Conferences

Clinical Orthopaedic Research
1. Chen C, Zhao Z, Jiang H. Axial traction straight leg raising test for type lumbar disc herniation. Chinese Journal of Spine and Spinal Cord 1992; 2(3):125- 126.
2. He SJ, Wang HG, Chen C. Scoliosis Surgical Treatment - 54 Clinical Cases Review. Chinese Journal of Spine and Spinal Cord 1994;4(3):124-125.
3. Lin X, Chen C. Treatment of lumbar disk herniation by herbal medicines and their pharmacologic mechanisms. China Journal of Chinese Materia Medica (Zhongguo Zhong Yao Za Zhi) 2007;32(3):186-91.
4. Dougherty P, Chen C, Zhang Y. CORR® Curriculum - Orthopaedic Education: Orthopaedic Surgery Education in China. Clin Orthop Relat Res 2017; 475:35–38 / DOI 10.1007/s11999-016-5162-z
5. Michael Daniel, David Waters, Chaoyang Chen, Nicole Brouyette. “Tibial Schwannoma in multiple myeloma patient”. SAGE Open Medical Case Reports 2019. 10;7:2050313X19838441. doi: 10.1177/2050313 X19838441. eCollection.
6. Jonathan Lynch, Charles C. Yu, Chaoyang Chen, Stephanie Muh. “MRI and US in distal bicep tendon rupture”. Orthop Trauma Surg Res 2019, doi: 10.1016/j.otsr.2019.01.021.
7. Oliver Scotting, Wayne North, Craig Silverton, Fawaz Hussain, Chaoyang Chen, Micheal Charters. Indwelling Urinary Catheter Necessary for Total Joint Arthroplasty Using Epidural Anesthesia. Journal of Arthroplasty 2019. https://doi.org/10.1016/j.arth.2019.05.047.
8. Felicity Fisk, MD; Sreten Franovic, MS, BS; Joseph Tramer, MD; Caleb M Gulledge, BS; Noah A Kuhlmann, MS, BS; Chaoyang Chen, MD, PhD; Vasilios Moutzouros, MD; Stephanie Muh, MD; Eric C Makhni. PROMIS CAT Forms Demonstrate Early Responsiveness in Patients Undergoing Rotator Cuff Repair across Multiple Health Domains. J Shoulder Elbow Surg. 2019 Dec;28(12):2427-2432. doi: 10.1016/j.jse.2019.04.055.
9. Franovic S, Gulledge CM, Kuhlmann NA, Williford TH, Chen C, Makhni EC. Establishing "Normal" Patient-Reported Outcomes Measurement Information System Physical Function and Pain Interference Scores: A True Reference Score According to Adults Free of Joint Pain and Disability. JBJS Open Access. 2019 Dec 10;4(4):e0019. doi: 10.2106/JBJS.OA.19.00019. eCollection 2019 Oct-Dec.
10. Kyle Schultz, Jeff Osborne, Karen Nelson, Vishnu Potini, Chaoyang Chen, Andrew Aljuni, Asheesh Bedi, James Bookout, Michael Yusaf, Shariff K Bishai. Intra- and interobserver reliability for predicting hip preservation versus hip arthroplasty utilizing plain radiographs with comparison of surgeon specialization. Journal of Hip Preservation Surgery. 2020 Feb 10, hnaa005, https://doi.org/10.1093/jhps/hnaa005, PMID: 32382432
11. Elizabeth Ann Klag, Kelechi R Okoroha, Gabriel Sheena; Noah A Kuhlmann; Chaoyang Chen; Stephanie J Muh. Does the use of a peri-articular anesthetic cocktail provide adequate pain control following shoulder arthroplasty? Journal of Shoulder and Elbow Surgery 2020, (DOI: 10.1177/1758573220916916)
12. Noah A Kuhlmann, Kevin A Taylor, MD, Christopher P Roche, Sreten Franovic, Chaoyang Chen, Bradley C Carofino, Pierre-Henri Flurin, Thomas W Wright, Bradley S Schoch, Joseph D Zuckerman, Stephanie J Muh. Acute versus delayed reverse total shoulder arthroplasty for proximal humerus fractures in the elderly: Mid-term outcomes. Seminars in Arthroplasty 2020, DOI: https://doi.org/10.1053/j.sart.2020.05.007
13. Patrick Schafer,Ali Mehaidli,Mark Zekaj,Muhammad T Padela,Syed Ahmad Rizvi,Chaoyang Chen,Zain Sayeed,Hussein Darwiche. Assessing knee anatomy using Makoplasty software a case series of 99 knees. Journal of orthopaedics. 2020, 20,347-351. DOI: 10.1016/j.jor.2020.05.023. PMID: 32684671.
14. Christopher Cooke, Jeffrey Osborne, Nancy Jackson, Patrick Keating,Jeff Flynn, David Markel, Chaoyang Chen, Stephen Lemos. Acetaminophen, Bupivacaine, Duramorph, and Toradol: A comparison of Chondrocyte Viability and Gene Expression changes in Osteoarthritic Human Chondrocytes. Knee 2020 13;27(6):1746-1752. doi: 10.1016/j.knee.2020.10.019
15. Alex Hamilton, Caden Nowak, Chaoyang Chen, Hussein Darwiche. Differences in immediate post-operative outcomes between robotic-assisted TKA and conventional TKA. Arthroplasty Today. 2021 Feb 27;8:57-62. doi: 10.1016/j.artd.2021.01.017. PMID: 33718557
16. Sreten Franovic; Yang Zhou; Emily Lau; Alexander D Pietroski; Noah A Kuhlmann; Chaoyang Chen; Stephanie J Muh. A Pilot Study for Assessing a Novel Method of Measuring Shoulder Activation in Healthy Volunteers Using Surface Electromyography. Arch Orthop, 2020, 1, 126 – 134.
17. Sanar Yokhana, Sasha Stine, David Alex Hamilton, Lauren Smith, Abdul Zalikha, Chaoyang Chen, Hussein Darwiche. The prevalence of posterolateral tibial baseplate overhang: An anatomical CT study. J Orthop
2021 Feb 9;23:259-263. doi: 10.1016/j.jor.2021.02.002. PMID: 33679017
18. Edward Rozek, Allison Cracchiolo, Patrick Keating, Chaoyang Chen, Stephen Lemos. Evaluation of Educational Advancement following a Sports Medicine Rotation. International Journal of Sports and Exercise Medicine 2021,7(4),1-6. DOI: 10.23937/2469-5718/1510196.
19. Lau E, Pietroski A, Franovic S, Zhou Y, Kuhlmann N, Chen C, Muh S. Surface Electromyography Reveals Middle Deltoid as The Functionally Dominant Shoulder Muscle After Reverse Total Shoulder Arthroplasty. SN Comprehensive Clinical Medicine, 2021 DOI: 10.21203/rs.3.rs-519913/v1.
20. Yusik Cho, Alena Jalics, Ding Lv, Marissa Gilbert, Kathy Dickson, Dawei Chen, Hannah Joines, Brandon Kakos, Chaoyang Chen and Stephen Lemos. Predicting Rotator Cuff Tear Severity Using Radiographic Images and Machine Learning Techniques. ACM Conference Proceedings in ICCPR 2021 (ISBN: 978-1-4503-9043-9)


Orthopaedic Biomechanics and Sports Medicine
21. Micah Lissy, Jeffrey Osborne, Patrick Keating, Nathan Richards, Chaoyang Chen, Stephen Lemos. Physeal-Sparing Posteromedial Portal Approach Reduced Distance between Guide Pin and Neurovascular Structures. Knee Surgery, Sports Traumatology, Arthroscopy (KSSTA) 2021. (DOI: 10.1007/s00167-020-06043-z) PMID: 32405665.
22. Timothy Doig, Paul Fagan, Todd Frush, Lisa Lovse, Chaoyang Chen, Stephen Lemos. The All-Inside All-Suture Technique Demonstrated Better Biomechanical Behaviors in Meniscus Radial Tear Repair. Knee Surgery, Sports Traumatology, Arthroscopy 2020 June (DOI: 10.1007/s00167-020-06078-2)
23. Halloran JP, Esquivel AO, Cracchiolo AM, Chen C, Lemos SE. The Role of the MPFL and MPTL in Patellar Stability – A Biomechanical Study. Arch Orthop. 2020; 1(2): 49-54.
24. Cheng Chen, Christine Chen, Xuesong Mei, Chaoyang Chen, Guoxin Ni, Stephen Lemos. Effects of Image Augmentation and Dual-layer Transfer Machine Learning Architecture on Tumor Classification. ICCPR '19: Proceedings of the 2019 8th International Conference on Computing and Pattern Recognition, October 2019, Pages 282–287. Publisher: Association for Computing Machinery, New York, NY, United States. ISBN:978-1-4503-7657-0. https://doi.org/10.1145/3373509.3373584.
25. Gui Yin, Xiaodong Zhang, Dawei Chen, Hanzhe Li, Jiangcheng Chen, Chaoyang Chen, Stephen Lemos. Processing Surface EMG Signals for Exoskeleton Motion Control. Frontiers in Neurorobotics. 2020 doi: 10.3389/fnbot.2020.00040.
26. Yang Zhou, Chaoyang Chen, Juan Ni Guoxin Ni, Min Li, Guanghua Xu, John Cavanaugh, Mark Cheng, Stephen Lemos. EMG Signal Processing for Hand Motion Pattern Recognition Using Machine Learning Algorithms. Archives of Orthopaedics 2020; 1(1): 17-26.

Orthopaedic Basic Research (Orthopaedic Pain, Neurophysiology)
27. Chen C, Cavanaugh JM, Song Z, Takebayashi T, Kallakuri S, Wooley PH. Effects of Nucleus Pulposus on Nerve Root Neural Activity, Mechanosensitivity, Axonal Morphology and Sodium Channel Expression. Spine 29(1):17-25, 2004.
28. Chen C, Cavanaugh JM, Ozaktay AC, Kallakuri S, King AI: The Effects of Phospholipase A2 on Nerve Root Function and Structure. Spine 22(10):1057-1064, 1997.
29. Takebayashi T, Cavanaugh JM, Ozaktay AC, Kallakuri S, Chen C. Effect of Nucleus Pulposus on the Neural Activity of the Dorsal Root Ganglion. Spine 26(8):940-945, 2001.
30. Kallakuri S, Singh A, Chen C, Cavanaugh JM. Demonstration of Substance P, Calcitonin Gene Related Peptide and Protein Gene Product 9.5 Containing Nerve Fibers in Human Cervical Facet Joint Capsules. Spine, 29:11, 1182-1186, 2004.
31. Kallakuri S, Cavanaugh JM, Takebayashi T, Chen C, Yang SY, Wooley PH, Ozaktay AC. Epidural Application of Allografted Nucleus Pulposus in Rats: Cytokine Expression and Behavioral Changes. European Spine Journal DOI: 10.1007/s00586-004-0835-9
32. Chen C, Lu Y, Cavanaugh JM, Kallakuri S, Patwardhan A. Recording of Neural Activity from Goat Cervical Facet Joint Capsule Using Custom-Designed Miniature Electrodes. Spine 2005;30:1367-1372.
33. Lu Y, Chen C, Kallakuri S, Patwardhan A, Cavanaugh JM. Development of an In Vivo Method to Investigate Biomechanical and Neurophysiological Properties of Spine Facet Joint Capsules. European Spine Journal 2005;14(6);565-72.
34. Lu Y, Chen C, Kallakuri S, Patwardhan A, Cavanaugh JM: Neurophysiological and Biomechanical Characterization of Goat Cervical Facet Joint Capsules. Journal of Orthopaedic Research 2005;23(4):779-787.
35. Cavanaugh JM, Lu Y, Chen C, Kallakuri S. Pain Generation in Lumbar Facet Joints. J Bone Joint Surg Am: 2006 Apr; 88 Suppl 2:63-7.
36. Takebayashi T, Cavanaugh JM, Kallakuri S, Chen C, Yamashita T. Sympathetic afferent units from lumbar intervertebral discs. J Bone Joint Surg Br. 2006 Apr;88(4):554-7.
37. Chen C, Lu Y, Kallakuri S, Patwardhan A, Cavanaugh JM. Distribution of A-delta and C-fiber receptors in the cervical facet joint capsule and their response to stretch. J Bone Joint Surg Am: 2006 Aug; 88(8):1807-16.
38. Kallakuri S, Singh A, Lu Y, Chen C, Patwardhan A, Cavanaugh JM. Tensile stretching of cervical facet joint capsule and related axonal changes. Eur Spine J. 2008 Apr;17(4):556-63.
39. Kallakuri S, Li Y, Chen C, Cavanaugh JM. Innervation of cervical ventral facet joint capsule: Histological evidence. World J Orthop 2012 February 18; 3(2): 10-14. doi:10.5312/wjo.v3.i2.10
40. Xu P, Wang H, Liu Z, Mu W, Xu S, Chen C, Cavanaugh JM. An Evaluation of 3D Image-Guided Technologies in Percutaneous Pelvic and Acetabular Lag Screw Placement. J Surg Res. 2013 Jun 22. doi:pii: S0022-4804(13)00557.

Ultrasonic Cutting Device Research (Sponsor Ethicon Inc)
41. Chen C, Kallakuri S, Vedpathak A, Chimakurthy C, Cavanaugh JM, Clymer J, Malaviya P. The Effects of Ultrasonic and Monopolar Electrosurgery Devices on Sciatic Nerve Physiology. British Journal of Neurosurgery 2012 Dec;26(6):856-63.
42. Bertke BD, Scoggins P, Welling AL, Widenhouse T, Chen C, Kallakuri S, Cavanaugh JM, Clymer JM, Amaral JF. Ex vivo and in vivo evaluation of an ultrasonic device for precise dissection, coagulation, and transection. Journal of Open Access Surgery 2015:8 1–7.
43. Chen C, Kallakuri S, Cavanaugh JM, Broughton D, Clymer JW. Acute and subacute effects of ultrasonic and electrosurgery devices on nerve physiology. British Journal of Neurosurgery 2015. 2015 Mar 26:1-5.
44. Chen C, Cavanaugh JM, Kallakuri S, Tanimoto T, Broughton D, Clymer JW, Widenhouse TW, Amaral JF. Acute effects of ultrasonic shears and monopolar electrosurgery on sciatic nerve electrophysiology. Br J Neurosurg. 2015 Jul 4; 29(4): 569–573.

Nerve Injury Tolerance
45. Lu Y, Chen C, Kallakuri S, Patwardhan A, and Cavanaugh JM. Neural response of cervical facet joint capsule to stretch: a potential whiplash pain mechanism. Stapp Car Crash Journal 2005-22-0003, 49:49-65. Stapp Award for Best Paper
46. Singh A, Lu Y, Chen C, Cavanaugh JM. Mechanical properties of spinal nerve roots subjected to tension at different strain rates. J Biomech 2006; 39(9):1669-76.
47. Singh A, Lu Y, Chen C, Kallakuri S, Cavanaugh JM. A new model of traumatic axonal injury to determine the effects of strain and displacement rates. Stapp Car Crash Journal. 2006-22-0023, 50:601-623. Stapp Student Award for Best Paper
48. Azar NR, Kallakuri S, Chen C, Cavanaugh JM. Strain and Load Thresholds for Cervical Muscle Recruitment in Response to Quasi-static Tensile Loading of the Caprine C5-C6 Facet Joint Capsule. Journal of Electromyography and Kinesiology 2009 Dec;19(6):e387-94.
49. Singh A, Kallakuri S, Chen C, Cavanaugh JM. Structural and functional changes in nerve roots due to tension at various strains and strain rates: an in-vivo study. J Neurotrauma. 2009 Apr;26(4):627-40.
50. Azar NR, Kallakuri S, Chen C, Cavanaugh JM. Muscular Response to Physiologic Tensile Stretch of the Caprine C5/6 Facet Joint Capsule: Dynamic Recruitment Thresholds and Latencies. Stapp Car Crash Journal 2011 Nov;55:441-60.
51. Chen C, Yaldo J, Virk G, Kallakuri S, Tanimoto K, Cavanaugh JM. Determination of Spinal Nerve Injury Tolerance to Stretch. Journal of Neurotrauma 2012,29:A-1-A-230. Page A79-B07.
52. Chen C, Cheng B, Huang C, Jiang B, Chen D, Tao X. Finite Element Analysis of Cervical Spinal Nerve Tissue Tolerance to Whiplash Injury - A Preliminary Study. Proceedings of the 34th FISITA World Automotive Congress 2012. In: Proceedings of the FISITA 2012 world automotive congress, Lecture notes in electrical engineering 197. Springer, Berlin/Heidelberg 2013, pp 433– 448. doi:10.1007/978-3-642-33805-2_35.
53. Xu P, Liu Z, Zhou D, Mu W, Chen C. Mechanism of nerve root stretch injury. Chinese Journal of Tissue Engineering Research. 2013, Vol 17(39):6997-7002.

Human Machine Interaction/ Ergonomics/Human Factors
54. Chen C, Cheng B, Wang Z, Chen D, Tao X, Cavanaugh JM. Back muscle activity while operating a vehicle. In: Proceedings of the FISITA 2012 world automotive congress, vol 197. Lecture notes in electrical engineering. Springer, Berlin/Heidelberg, pp 801– 811. doi:10.1007/978-3-642-33805-2_65.
55. Tao X, Cheng B, Wang B, Zhang F, Li G, Chen C. SEMG based prediction for lumbar muscle fatigue during prolonged driving. Paper presented at The 34th FISITA world automotive congress. In: Proceedings of the FISITA 2012 world automotive congress, vol 197. Lecture notes in electrical engineering. Springer, Berlin/Heidelberg, pp 773–783. doi:10.1007/978-3-642-33835-9_70.
56. Zeng C, Li N, Wang W, Chen C. An improved group searching optimization method. Transducer and Microsystem Technologies. 2012,31(9):28-31.
57. Zeng C, Li N, Wang W, Chen C. Registration of medical images using group search optimizer combined with Powell's method. Journal of Yunnan University, 2013,35(5):603-609.
58. Tao X, Cheng B, Wang W, Chen C. A Fatigue-Included Prediction Model for Drivers’ Lumbar Comfort during Prolonged Driving. Annual Meeting of SAE 2014, 14B-0258.
59. Zeng C, Jiang Q, Chen C, Xu M. Application of Heart Rate Variability Analysis on Pain Detection for Newborns. Acta Phys. Sin, 2014, 63 (20): 208704. doi:10.7498/aps.63.208704
60. Gao Z, Li Z, Zhao K, Zhao H, Yu H, Chen C. Characterization of Neck Muscle Response during Crash using A simulator. Automotive Engineering. 2014 (12);1466-1472. (In Chinese).
61. Gao Z, Fan D, Wang D, Zhao H, Zhao K, Chen C. Muscle activity and co-contraction of musculoskeletal model during steering maneuver. Bio-medical materials and engineering 01/2014; 24(6):2697-706.
62. Meng X, Tao X, Wang W, Zhang C, Zhou C, Jin X, Cheng B, Cavanaugh JM, Chen C. Effects of sinusoidal whole body vibration frequency on drivers’ muscle responses. International Journal of SAE 2015. Paper #: 2015-01-1396. DOI:10.4271/2015-01-1396.
63. Zeng C, Jiang Q, Chen C, Xu M. An EMD based method for detrending RR interval series without resampling. J. Cent. South Univ. (2015) 22: 567− 574. DOI: 10.1007/s11771-015-2557-z.
64. Gao Z, Li C, Hu H, Zhao H, Chen C, Yu H. Simulator Study of Young Driver's Instinctive Response of Lower Extremity to a Collision. Traffic Injury Prevention 2015. DOI:10.1080/ 15389588.2015.1081898
65. Gao Z, Li C, Hu H, Zhao H, Chen C, Yu H. Experimental study of young male drivers' responses to vehicle collision using EMG of lower extremity. Biomed Mater Eng 2015 Aug;26 Suppl 1:S563-73.
66. Gao Z, Li C, Hu H, Zhao H, Chen C, Yu H. Study of cervical muscle response and injury of driver during a frontal vehicle collision. Biomed Mater Eng 2015 Aug;26 Suppl 1:S619-27.
67. Zhenhai Gao, Chuzhao Li, Hongyu Hu, Hui Zhao, Chaoyang Chen, Huili Yu. Study of the influence of muscle activation on a driver's lower extremity injury. International Journal of Crashworthiness 2016. DOI:10.1080/13588265.2016.1148320
68. Gao Z, Li, C, Hu H, Chen C. et al. "Study of Muscle Activation of Driver’s Lower Extremity at the Collision Moment." SAE International, Technical Paper 2016-01-1487, 2016, doi:10.4271/2016-01-1487.
69. Chaoyang Chen,Wenjun Wang,Chaofei Zhang,Bo Cheng,Chao Zeng,Xiangjie Meng,John M Cavanaugh. Quantitative Analysis Electroencephalography for Determination of Drowsy Driving. Journal of Automotive Safety and Energy 2016. DOI: 10.3969/j.issn.1674-8484.2016.02.006.
70. Zeng C, Wang W, Chen C, Zhang C, Cheng B,Cavanaugh JM. Detrended Fluctuation Analysis of Heart Rate Variability and Encephalography in Driver’s Fatigue State. Transducer and Microsystem Technologies 2016,35,1:7-10. DOI:10.13873/J.1000-9787(2016)01-007-04.
71. Zhang Chaofei, Wang Wenjun, Chen Chaoyang, Chao Zeng, Dennis Anderson, Cheng Bo. Determination of Optimal Electroencephalography Recording Locations for Detecting Drowsy Driving. IET Intelligent Transport Systems 2018, 12(5). DOI: 10.1049/iet-its.2017.0083
72. Zeng Chao, Wang Wenjun,Li Yan,Chen Chaoyang, Zhang Chaofei,Cheng Bo. Nonlinear heart rate variability features of drivers in fatigue state considering gender factor. Journal of Southeast University (Natural Science Edition), 2019,49(3):595-602. 10.3969/j.issn.1001-0505.2019.03.027.
73. C Zeng, W Wang, C Chen, C Zhang, B Cheng. Poincaré Plot Indices of Heart Rate Variability for Monitoring Driving Fatigue. 19th COTA International Conference of Transportation Professionals 2019, Nanjing China. https://doi.org/10.1061/9780784482292.059
74. Chao Zeng, Wenjun Wang *, Chaoyang Chen, Chaofei Zhang, Bo Cheng. Sex Differences in Time-Domain and Frequency-Domain Heart Rate Variability Measures of Fatigued Drivers. International Journal of Environmental research and Public Health (IJERPH) 2020. Nov; 17(22): 8499. doi: 10.3390/ijerph17228499.
75. Chao Zeng, Wenjun Wang *, Chaoyang Chen, Chaofei Zhang, Bo Cheng. Design of synchronization device for simulation driving experiment and experimental teaching application. Experimental Technology and Management 2000. 37:99-102. DOI: 10.16791/j.cnki.sjg.2020.03.022

Nanotechnology and Implantable Nerve Sensor
76. Yi W, Chen C, Feng Z, Xu Y, Zhou C, Masurkar N, Cavanaugh JM; Cheng M. A Flexible and Implantable Microelectrode Arrays Using High-temperature Grown Vertical Carbon Nanotubes and a Biocompatible Polymer Substrate. Nanotechnology. 2015 Mar 27;26(12):125301. doi: 10.1088/0957-4484/26/12/125-301.
77. Tian P, Chen C, Hu J, Qi J, Wang Q, Chen J, Cavanaugh J, Peng Y, Cheng M. A novel fabrication method of carbon electrodes using 3D printing and chemical modification process. Biomed Microdevices. 2017 Nov 23;20(1):4. doi: 10.1007/s10544-017-0247-3.
78. Tian P, Yi W, Chen C, Hu J, Qi J, Zhang B, Cheng MM. Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface. Biomed Microdevices. 2018 Feb 19;20(1):21. doi: 10.1007/s10544-018-0268-6.
79. Xinuo Zhang, Chaoyang Chen, Guoxin Ni, Yong Hai, Biao Chen, Yang Zhou, Boshen Zhang, Gui Chen, Mark Ming-Cheng Cheng. Carbon multi‐electrode arrays as peripheral nerve interface for neural recording and nerve stimulation. Medical Devices and Sensor. 2019. DOI: 10.1002/mds3.10026
80. Biao Chen, Boshen Zhang, Chaoyang Chen, Jie Hu, Jin Qi, Pan Tian, Xinuo Zhang, Guoxin Ni, Mark Cheng. Dual-function high-aspect ratio glassy carbon neural electrode arrays for brain machine interface. Biomedical Microdevices 2020 (DOI: 10.1007/s10544-020-00498-0).
81. Tonya J. Whitehead, Elizabeth Mays, Monica Prasad, Anthony Mora, Chaoyang Chen, Assadollah Mazhari, Jean Peduzzi, Harini Sundararaghavan. Mechanical, Topographical and Chemical Cues Combined with Physical Therapy for Peripheral Nerve Injuries. Regenerative Medicine 2020. Dec 7. doi: 10.2217/rme-2020-0059

Blast Induced Brain Injury and Biomechanical Mechanisms
82. Zhang L, Feng K, Chen C, Jin X, Kallakuri K, Cavanaugh JM, King AI. Mechanical Repsonse of Swine Exposed to Free-Filed Blasts. Journal of Neurotrauma 2015, 32:A-1-A-152. Page A-105. DOI:10.1089/neu.2015.29000.abstracts.
83. Zhang L, Kallakuri S, Desai A, Mathei J, Dawe E, Feng K, Chen C, Cavanaugh JM, King AI. Open Field Primary Blast Exposure Induces Neuronal and Glial Alternations in Frontal Cortex. Journal of Neurotrauma 2015, 32:A-1-A-152. Page B2-12. DOI:10.1089/neu.2015. 29000.abstracts.
84. Chen C, Zhou C, Cavanaugh JM, Kallakuri S, Desai A, Zhang L, King AI. Quantitative Electroencephalography Analysis of Blast Induced Brain Injury in A Swine Model. Brain Injury 2017. DOI: 10.1080/02699052.2016.1216603.
85. Srinivasu Kallakuri, Alok Desai, Ke Feng, Sharvani Tummala, Tal Saif, Chaoyang Chen, Liying Zhang, John M Cavanaugh, Albert I King. Neuronal Injury and Glial Changes are Hallmarks of Open Field Blast Exposure in Swine Frontal Lobe. Plos One 2017, January 20, 2017
86. Feng K, Zhang L, Jin X, Chen C, Kallakuri S, Saif T, Cavanaugh J, King A. Biomechanical Responses of the Brain in Swine Subject to Free-Field Blasts. Front Neurol. 2016 Oct 24;7:179.

Brain Computer Interface and Robotic Neurorehabilitation
87. Chaoyang Chen, Guanghua Xu, John M Cavanaugh. Advance in Rehabilitative Intuitive Robotics. Journal of Applied Biotechnology and Bioengineering. 2016. DOI:10.15406/jabb.2016.01.00002.
88. Wenqiang Yan, Guanghua Xu, Min Li, Jun Xie, Chengcheng Han, Sicong Zhang, Ailing Luo, and Chaoyang Chen. Steady-State Motion Visual Evoked Potential (SSMVEP) Based on Equal Luminance Color Enhancement. PLoS One 2017 Jan 6;12(1):e0169642. doi: 10.1371/journal.pone.0169642.
89. Min Li; Guanghua Xu; Jun Xie; Chaoyang Chen. A review: Motor rehabilitation after stroke with control based on human intent. Proc Inst Mech Eng H. 2018 Feb 1:954411918755828. doi: 10.1177/0954411918755828.
90. Chengcheng Han, Guanghua Xu, Jun Xie, Sicong Zhang, Chaoyang Chen. Highly Interactive Brain-Computer Interface Based on Flicker-Free Steady-State Motion Visual Evoked Potential. Scientific Report 2018,8(1).
91. Min Li, Jiazhou Chen, Bo He, Guanghua Xu, Jun Xie, shengchen Zhu, Chaoyang Chen. Structure optimization and motion planning of a consecutive multiple-section hand exoskeleton. The Jounral of Xian Jiaotong University 2019 (10):1-11.
92. Yongyu Jiang, Christine Chen, Xiaodong Zhang, Wei Zhou, Chaoyang Chen and Stephen Lemos. Processing EEG Signal for Hand Motion Pattern Recognition Using CNN Machine Learning Algorithms". ACM Conference Proceedings in ICCPR 2020 (ISBN: 978-1-4503-8783-5) https://dl.acm.org/doi/abs/10.1145/3436369.3437433
93. Yang Zhou, Chaoyang Chen, Mark Cheng, Sreten Franovic, Stephanie Muh and Stephen Lemos. Real-Time Surface EMG Pattern Recognition for Shoulder Motions Based on Support Vector Machine. ACM Conference Proceedings in ICCPR 2020 (ISBN: 978-1-4503-8783-5). https://dl.acm.org/doi/abs/10.1145/3436369.3437434
94. Yongyu Jiang, Christine Chen, Xiaodong Zhang, Chaoyang Chen, Yang Zhou, Guoxin Ni, Stephanie Muh, Stephen Lemos. Shoulder Muscle Activation Pattern Recognition Based on sEMG and Machine Learning Algorithms. Computer Methods and Programs in Biomedicine 2020 https://doi.org/10.1016/j.cmpb.2020.105721
95. Yongyu Jiang, Xiaodong Zhang, Chaoyang Chen, Zhufeng Lu, Yachun Wang. Deep Learning Based Recognition of Hand Movement Intention EEG in Patients with Spinal Cord Injury. The Annual IEEE International Conference on CYBER Technology in Automation, Control, and Intelligent Systems. 2020. 10.1109/CYBER50695.2020.9279190.
96. Yang Zhou, Chaoyang Chen, Mark Cheng, Yousef Alshahrani, Sreten Franovic, Emily Lau, Guanghua Xu, Guoxin Ni, John M Cavanaugh, Stephanie Muh, Stephen Lemos. Comparison of Machine Learning Methods in sEMG Signal Processing for Shoulder Motion Recognition. Biomedical Signal Processing and Control 2021. https://doi.org/10.1016/j.bspc.2021.102577.
97. Yousef Alshahrani, Yang Zhou, Chaoyang Chen, Hannah Joines, Tangfei Tao, Guanghua Xu, Stephen Lemos. Performance Validation of An Upper Limb Exoskeleton Using Joint ROM Signal. Archives of Orthopaedics 2021; 2(1), 20-30.
98. Min Li, Chen Jiazhou, Guoying He, Lei Cui, Chaoyang Chen, Emanuele Lindo Secco, Wei Yao, Jun Xie, Guanghua Xu, Helge A. Wurdemann. Attention Enhancement for Exoskeleton assisted Hand Rehabilitation using Fingertip Haptic Stimulation. Front. Robot. AI, 2021 | https://doi.org/10.3389/frobt.2021.602091
99. Yang Zhou, Chaoyang Chen, Yousef Alshahrani, Mark Cheng, Guanghua Xu, Min Li, Wei Zhou, Linjing Wu, Brandon Kakos, Todd Frush, Stephen Lemos. Real-time Multiple-Channel Shoulder EMG Processing for a Rehabilitative Upper-limb Exoskeleton Motion Control Using ANN Machine Learning. IEEE Proceedings of 27th International Conference on Mechatronics and Machine Vision in Practice, Shanghai, China. Nov. 2021.
 

Awards and Honors

International Fellow, Annual Meeting of the International Society for the Study of the Lumbar Spine, Seattle, Washington 1994

Sofamor Danek Award for Outstanding Poster, Annual Meeting of the International Society for the Study of the Lumbar Spine, Seattle, Washington 1994

William D. Robinson Postdoctoral Fellowship Award, Arthritis Foundation, Michigan Chapter, Medical & Scientific Committee, 1997-1998.

Research Grant Award, Orthopaedic Research and Education Foundation, 1998-2000.

New Investigator Recognition Award. Annual Meeting of Orthopaedic Research Society, Washington DC, 2004

Stapp Student Award for Best Paper, Stapp Car Crash Conference, Washington DC, 2005

John Paul Stapp Best Paper Award, Stapp Car Crash Conference, 2005

Stapp Student Award for Best Paper, Anita Singh, Stapp Car Crash Conference, Dearborn,
Michigan 2006

Stapp Student Award for Best Paper, Nadia Azar, Stapp Car Crash Conference, Dearborn,
Michigan 2011

The Third Prize Award. “Low-Cost Development of High Quality Automotive Safety Products.” China Association of Automobile Manufacturers (CAAM) and Detroit Chinese Business Association (DCBA) Detroit, June 2014.

The Best Oral Presentation, International Conference on Computing and Pattern Recognition, Association of Computer Machinery, Xiemen, China, 2020.

Other Professional Experience

  • Guest Professor, Department of Rehabilitation, Fujian Medical University, Fuzhou, Fujian, China, 2016-2019
  • Guest Lecturer, School of Mechanic Engineering, Xian Jaiotong University, Xian, Shanxi, China, 2016-2019,
  • Guest Research Fellow, Tsinghua University, Beijing, China, 2011-2017. 
  • Program Chair. International Conference of Biomedical Image, Signal Processing, Newark, NJ, USA, 2017.
  • Session Chair, Assistive Technology, Annual Meeting of Biomedical Engineering Society, Atlanta, GA, 2018.
  • Program Chair, The 8th International Conference on Computing and Pattern Recognition (ICCPR), Association of Computer Machinery, Beijing, China, 2019.
  • Publicity Chair, The 9th International Conference on Computing and Pattern Recognition (ICCPR), Association of Computer Machinery, Xieman, China, 2020.

 

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